New biological activities of Casimiroa edulis leaf extract and isolated compounds.

Awaad, Amani S, Al-Jaber, Nabilah A, Soliman, Gamal A, Al-Outhman, Mounerah R, Zain, Mohamed E, Moses, John E, El-Meligy, Reham M (March 2012) New biological activities of Casimiroa edulis leaf extract and isolated compounds. Phytotherapy Research, 26 (3). pp. 452-457. ISSN 0951-418X

DOI: 10.1002/ptr.3690


The phytochemical investigation of Casimiroa edulis Llave et Lex (Rotaceae) afforded four coumarins: umbelliferone (1), esculetin (2), imperatorin (3) and xanthotoxol (4). The identification of these compounds was achieved by using a combination of m.p., UV, EI-mass, ¹H NMR and ¹³C NMR spectroscopy. Essential oil extracts were analysed by GC/MS leading to the identification of 60 components. Sesquiterpene hydrocarbons accounted for the major make up of the oil. Microbiological screenings of the oil and successive plant fractions were performed, showing promising activity against a number of microorganisms with Minimum inhibitory concentrations (MIC) comparable to the standard antibiotics such as chloramphenicol and kanamycin. The plant ethanol extract (400 mg/kg) and the isolated coumarins (60 mg/kg) showed anticoagulant activity. Analyses to determine the activity of the extracts on liver and kidney function were performed, revealing no negative or detrimental effects.

Item Type: Paper
Subjects: chemistry
organism description > plant
CSHL Authors:
Communities: CSHL labs > Moses lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: March 2012
Date Deposited: 06 Jul 2021 20:52
Last Modified: 06 Jul 2021 20:52

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