Interactions of marine-derived γ-pyrone natural products with phospholipid membranes.

Powell, Kimberley J, Sharma, Pallavi, Richens, Joanna L, Davis, Benjamin M, Moses, John E, O'Shea, Paul (November 2012) Interactions of marine-derived γ-pyrone natural products with phospholipid membranes. Physical Chemistry Chemical Physics, 14 (42). pp. 14489-14491. ISSN 1463-9076

Abstract

The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (3), and its proposed biosynthetic precursors (1 and 2) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates the observed data. The possibility that localised lipid domains within the membrane have an effect on the localisation is also addressed.

Item Type: Paper
Subjects: chemistry
physics > biophysics > membrane dynamics
organs, tissues, organelles, cell types and functions > tissues types and functions > membranes
CSHL Authors:
Communities: CSHL labs > Moses lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 14 November 2012
Date Deposited: 02 Jul 2021 18:33
Last Modified: 02 Jul 2021 18:33
URI: https://repository.cshl.edu/id/eprint/40245

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