Powell, Kimberley J, Sharma, Pallavi, Richens, Joanna L, Davis, Benjamin M, Moses, John E, O'Shea, Paul (November 2012) Interactions of marine-derived γ-pyrone natural products with phospholipid membranes. Physical Chemistry Chemical Physics, 14 (42). pp. 14489-14491. ISSN 1463-9076
Abstract
The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (3), and its proposed biosynthetic precursors (1 and 2) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates the observed data. The possibility that localised lipid domains within the membrane have an effect on the localisation is also addressed.
| Item Type: | Paper |
|---|---|
| Subjects: | chemistry physics > biophysics > membrane dynamics organs, tissues, organelles, cell types and functions > tissues types and functions > membranes |
| CSHL Authors: | |
| Communities: | CSHL labs > Moses lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 14 November 2012 |
| Date Deposited: | 02 Jul 2021 18:33 |
| Last Modified: | 02 Jul 2021 18:33 |
| URI: | https://repository.cshl.edu/id/eprint/40245 |
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