Multicenter Validation of the CamGFR Model for Estimated Glomerular Filtration Rate.

Williams, Edward H, Connell, Claire M, Weaver, James MJ, Beh, Ian, Potts, Harry, Whitley, Cameron T, Bird, Nicholas, Al-Sayed, Tamer, Monaghan, Phillip J, Fehr, Martin, Cathomas, Richard, Bertelli, Gianfilippo, Quinton, Amy, Lewis, Paul, Shamash, Jonathan, Wilson, Peter, Dooley, Michael, Poole, Susan, Mark, Patrick B, Bookman, Michael A, Earl, Helena, Jodrell, Duncan, Tavaré, Simon, Lynch, Andy G, Janowitz, Tobias (December 2019) Multicenter Validation of the CamGFR Model for Estimated Glomerular Filtration Rate. JNCI Cancer Spectrum, 3 (4). pkz068. ISSN 2515-5091

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Abstract

Important oncological management decisions rely on kidney function assessed by serum creatinine-based estimated glomerular filtration rate (eGFR). However, no large-scale multicenter comparisons of methods to determine eGFR in patients with cancer are available. To compare the performance of formulas for eGFR based on routine clinical parameters and serum creatinine not calibrated with isotope dilution mass spectrometry, we studied 3620 patients with cancer and 166 without cancer who had their glomerular filtration rate (GFR) measured with an exogenous nuclear tracer at one of seven clinical centers. The mean measured GFR was 86 mL/min. Accuracy of all models was center dependent, reflecting intercenter variability of isotope dilution mass spectrometry-creatinine measurements. CamGFR was the most accurate model for eGFR (root-mean-squared error 17.3 mL/min) followed by the Chronic Kidney Disease Epidemiology Collaboration model (root-mean-squared error 18.2 mL/min).

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders organs, tissues, organelles, cell types and functions > organs types and functions > kidney organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions
CSHL Authors:	Janowitz, Tobias
Communities:	CSHL labs > Janowitz lab CSHL Cancer Center Program > Cellular Communication in Cancer Program
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	December 2019
Date Deposited:	07 May 2021 20:03
Last Modified:	05 Feb 2024 21:02
PMCID:	PMC6846361
URI:	https://repository.cshl.edu/id/eprint/40064

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