Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex.

Wang, Bor-Shuen, Bernardez Sarria, Maria Sol, An, Xu, He, Miao, Alam, Nazia M, Prusky, Glen T, Crair, Michael C, Huang, Z Josh (February 2021) Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex. Neuron, 109 (3). 502-515.e7. ISSN 0896-6273

URL: https://www.ncbi.nlm.nih.gov/pubmed/33290732

DOI: 10.1016/j.neuron.2020.11.004

Abstract

In mammals with binocular vision, integration of the left and right visual scene relies on information in the center visual field, which are relayed from each retina in parallel and merge in the primary visual cortex (V1) through the convergence of ipsi- and contralateral geniculocortical inputs as well as transcallosal projections between two visual cortices. The developmental assembly of this binocular circuit, especially the transcallosal pathway, remains incompletely understood. Using genetic methods in mice, we found that several days before eye-opening, retinal and callosal activities drive massive apoptosis of GABAergic chandelier cells (ChCs) in the binocular region of V1. Blockade of ChC elimination resulted in a contralateral eye-dominated V1 and deficient binocular vision. As pre-vision retinal activities convey the left-right organization of the visual field, their regulation of ChC density through the transcallosal pathway may prime a nascent binocular territory for subsequent experience-driven tuning during the post-vision critical period.

Item Type:	Paper
Subjects:	organism description > animal organism description > animal behavior organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > chandelier cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > chandelier cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > chandelier cells organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > retina organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > tissues types and functions organism description > animal behavior > vision organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:	He, Miao Wang, Bor-Shuen An, Xu Huang, Z. Josh
Communities:	CSHL labs > Huang lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	3 February 2021
Date Deposited:	06 May 2021 14:56
Last Modified:	25 Jan 2024 20:45
PMCID:	PMC7943176
URI:	https://repository.cshl.edu/id/eprint/40001

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