Sharma, P., Bhat, S. V., Prabhath, M. R. R., Molino, A., Nauha, E., Wilson, D. J. D., Moses, J. E. (July 2018) Synthesis of 1,2,4-Triazol-3-imines via Selective Stepwise Cycloaddition of Nitrile Imines with Organo-cyanamides. Org Lett, 20 (14). pp. 4263-4266. ISSN 1523-7052
Abstract
A convenient method for the synthesis of 1,2,4-triazol-3-imines through a selective, formal, 1,3-dipolar cycloaddition of organo-cyanamide ions with nitrile imine dipoles is reported. Hydrolysis of the 1,2,4-triazol-3-imines yields the corresponding 1,2,4-triazol-5-ones. A stepwise mechanism, supported by DFT calculations, is invoked to explain the reaction selectivity.
| Item Type: | Paper |
|---|---|
| CSHL Authors: | |
| Communities: | CSHL labs > Moses lab |
| Depositing User: | Matthew Dunn |
| Date: | 20 July 2018 |
| Date Deposited: | 08 Jan 2021 17:30 |
| Last Modified: | 08 Jan 2021 17:30 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/39581 |
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