Powell, Kimberley J., Richens, Joanna L., Bramble, Jonathan P., Han, Li-Chen, Sharma, Pallavi, O'Shea, Paul, Moses, John E. (March 2018) Photochemical activity of membrane-localised polyketide derived marine natural products. Tetrahedron, 74 (12). pp. 1191-1198. ISSN 0040-4020
Abstract
Marine organisms rely upon complex bio-chemical systems to manage photo-induced oxidative damage as part of a sophisticated chemical defense. Using a combination of synthetic chemistry and biophysical techniques, we provide evidence to support the notion that marine derived polyene γ-pyrone metabolites of sacoglossan molluscs become localised at cell membranes where they influence the total absorption of the harmful radiation by the lipid membrane, thereby functioning as sunscreen agents. We also report two new hyperperoxide analogues of the putative polyene biosynthetic precursors that themselves are likely candidate natural products.
| Item Type: | Paper |
|---|---|
| CSHL Authors: | |
| Communities: | CSHL labs > Moses lab |
| Depositing User: | Matthew Dunn |
| Date: | 22 March 2018 |
| Date Deposited: | 08 Jan 2021 17:29 |
| Last Modified: | 08 Jan 2021 17:29 |
| URI: | https://repository.cshl.edu/id/eprint/39579 |
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