A synthetic approach to kingianin A based on biosynthetic speculation

Sharma, P., Ritson, D. J., Burnley, J., Moses, J. E. (October 2011) A synthetic approach to kingianin A based on biosynthetic speculation. Chem Commun (Camb), 47 (38). pp. 10605-7. ISSN 1359-7345

URL: https://pubmed.ncbi.nlm.nih.gov/21863194/
DOI: 10.1039/c1cc13949e


A synthetic approach towards the structurally complex dimer, kingianin A is reported. The strategy involved a cascade of complexity generating reactions, inspired through biosynthetic speculation. A concise protecting group free synthesis of the proposed monomeric precursor pre-kingianin A has been achieved using a tandem Stille cross-coupling reaction and electrocyclisation process. However, preliminary studies of the key dimerisation reaction have been conducted, which indicate that the process is not spontaneous, raising questions as to the origin of this complex natural product.

Item Type: Paper
Additional Information: Chemical communications (Cambridge, England)
CSHL Authors:
Communities: CSHL labs > Moses lab
Depositing User: Matthew Dunn
Date: 14 October 2011
Date Deposited: 08 Jan 2021 18:38
Last Modified: 08 Jan 2021 18:38
URI: https://repository.cshl.edu/id/eprint/39548

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving