Sharma, P., Ritson, D. J., Burnley, J., Moses, J. E. (October 2011) A synthetic approach to kingianin A based on biosynthetic speculation. Chem Commun (Camb), 47 (38). pp. 10605-7. ISSN 1359-7345
Abstract
A synthetic approach towards the structurally complex dimer, kingianin A is reported. The strategy involved a cascade of complexity generating reactions, inspired through biosynthetic speculation. A concise protecting group free synthesis of the proposed monomeric precursor pre-kingianin A has been achieved using a tandem Stille cross-coupling reaction and electrocyclisation process. However, preliminary studies of the key dimerisation reaction have been conducted, which indicate that the process is not spontaneous, raising questions as to the origin of this complex natural product.
| Item Type: | Paper |
|---|---|
| Additional Information: | Chemical communications (Cambridge, England) |
| CSHL Authors: | |
| Communities: | CSHL labs > Moses lab |
| Depositing User: | Matthew Dunn |
| Date: | 14 October 2011 |
| Date Deposited: | 08 Jan 2021 18:38 |
| Last Modified: | 08 Jan 2021 18:38 |
| URI: | https://repository.cshl.edu/id/eprint/39548 |
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