Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and "click" linker

Sharma, P., Moses, J. E. (June 2010) Ethynyldiisopropylsilyl: a new alkynylsilane protecting group and "click" linker. Org Lett, 12 (12). pp. 2860-3. ISSN 1523-7052

DOI: 10.1021/ol100968t


A new silyl-based reagent has been developed for "catch and release" immobilization, combining click chemistry with silyl protection. The traditional "all carbon" attachment to solid supports in a silyl type linker was substituted with a stable triazole, easily assembled using the CuAAC reaction. The methodology introduces a novel ethynyldiiospropylchlorosilane reagent (EDIPS-Cl) as a functionalized protecting group linker.

Item Type: Paper
Additional Information: Organic letters
CSHL Authors:
Communities: CSHL labs > Moses lab
Depositing User: Matthew Dunn
Date: 18 June 2010
Date Deposited: 19 Apr 2021 20:24
Last Modified: 19 Apr 2021 20:24
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