Barral, K., Moorhouse, A. D., Moses, J. E. (April 2007) Efficient conversion of aromatic amines into azides: a one-pot synthesis of triazole linkages. Org Lett, 9 (9). pp. 1809-11. ISSN 1523-7060 (Print)1523-7052
Abstract
[reaction: see text] An efficient and improved procedure for the preparation of aromatic azides and their application in the Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition ("click reaction") is described. The synthesis of aromatic azides from the corresponding amines is accomplished under mild conditions with tert-butyl nitrite and azidotrimethylsilane. 1,4-Disubstituted 1,2,3-triazoles were obtained in excellent yields from a variety of aromatic amines without the need for isolation of the azide intermediates.
| Item Type: | Paper |
|---|---|
| Additional Information: | Organic letters |
| Uncontrolled Keywords: | Amines/*chemistry Azides/*chemical synthesis/chemistry Cross-Linking Reagents/*chemistry Molecular Structure Triazoles/*chemistry |
| CSHL Authors: | |
| Communities: | CSHL labs > Moses lab |
| Depositing User: | Matthew Dunn |
| Date: | 26 April 2007 |
| Date Deposited: | 19 Apr 2021 21:33 |
| Last Modified: | 19 Apr 2021 21:33 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/39530 |
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