Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry

Moorhouse, A. D., Santos, A. M., Gunaratnam, M., Moore, M., Neidle, S., Moses, J. E. (December 2006) Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. J Am Chem Soc, 128 (50). pp. 15972-3. ISSN 0002-7863 (Print)0002-7863

URL: https://pubmed.ncbi.nlm.nih.gov/17165715/

DOI: 10.1021/ja0661919

Abstract

A series of G-quadruplex stabilizing compounds have been prepared via click chemistry employing the Cu(I)-catalyzed Huisgen reaction. These compounds were shown to bind tightly to G-quadruplex DNA even in the presence of competing high concentrations of duplex DNA. Furthermore, a modified TRAP assay has shown that some of these compounds also inhibit telomerase at low micromolar concentration.

Item Type:	Paper
Additional Information:	Journal of the American Chemical Society
Uncontrolled Keywords:	DNA/*chemistry/genetics Fluorescence Resonance Energy Transfer G-Quadruplexes Ligands Models, Chemical Molecular Structure Temperature
CSHL Authors:	Moses, John E.
Communities:	CSHL labs > Moses lab
Depositing User:	Matthew Dunn
Date:	20 December 2006
Date Deposited:	19 Apr 2021 21:31
Last Modified:	19 Apr 2021 21:31
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/39529

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