Behavior- And Modality-General Representation of Confidence in Orbitofrontal Cortex

Masset, P., Ott, T., Lak, A., Hirokawa, J., Kepecs, A. (June 2020) Behavior- And Modality-General Representation of Confidence in Orbitofrontal Cortex. Cell, 182. ISSN 0092-8674

Abstract

Every decision we make is accompanied by a sense of confidence about its likely outcome. This sense informs subsequent behavior, such as investing more-whether time, effort, or money-when reward is more certain. A neural representation of confidence should originate from a statistical computation and predict confidence-guided behavior. An additional requirement for confidence representations to support metacognition is abstraction: they should emerge irrespective of the source of information and inform multiple confidence-guided behaviors. It is unknown whether neural confidence signals meet these criteria. Here, we show that single orbitofrontal cortex neurons in rats encode statistical decision confidence irrespective of the sensory modality, olfactory or auditory, used to make a choice. The activity of these neurons also predicts two confidence-guided behaviors: trial-by-trial time investment and cross-trial choice strategy updating. Orbitofrontal cortex thus represents decision confidence consistent with a metacognitive process that is useful for mediating confidence-guided economic decisions.

Item Type:	Paper
Subjects:	organism description > animal organism description > animal behavior organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organism description > animal behavior > decision making organism description > animal > mammal organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > prefrontal cortex organism description > animal > mammal > rodent > rat organism description > animal > mammal > rodent > rat organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Kepecs, Adam Masset, Paul Ott, Torben Lak, Armin Hirokawa, Junya
Communities:	CSHL labs > Kepecs lab School of Biological Sciences > Publications
Depositing User:	Adrian Gomez
Date:	2 June 2020
Date Deposited:	08 Jun 2020 15:12
Last Modified:	01 Feb 2024 16:10
PMCID:	PMC8083070
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/39491

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