Human-tumor-derived cell lines contain common and different transforming genes

Perucho, M., Goldfarb, M., Shimizu, K., Lama, C., Fogh, J., Wigler, M. H. (December 1981) Human-tumor-derived cell lines contain common and different transforming genes. Cell, 27 (3 Pt 2). pp. 467-76.

URL: https://www.ncbi.nlm.nih.gov/pubmed/6101201
DOI: 10.1016/0092-8674(81)90388-3

Abstract

We have screened different cultured cell lines established from human tumors for the ability of their DNAs to induce transformed foci in NIH/3T3 cells. Based on restriction endonuclease digestions and the presence of human sequences in mouse transformants, we conclude that five of these human tumor cell lines contain a gene or genes capable of transforming mouse cells and that at least three different transforming genes are present in these five lines.

Item Type: Paper
Subjects: organism description > animal > mammal > rodent > mouse
CSHL Authors:
Communities: Cold Spring Harbor Laboratory of Quantitative Biology
Depositing User: Elizabeth Pessala
Date: December 1981
Date Deposited: 22 May 2020 17:54
Last Modified: 22 May 2020 17:54
URI: https://repository.cshl.edu/id/eprint/39431

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving