Lukey, M. J., Cerione, R. A. (August 2015) Rho GTPases. In: Encyclopedia of Cell Biology. Elsevier, pp. 731-740. ISBN 978-0-12-394796-3
Abstract
The Ras-homology (Rho) GTPases were initially linked to regulation of actin cytoskeletal architecture, maintenance of cell shape and polarity, and to cell migration. Subsequent studies have shown that Rho GTPases are involved in highly diverse cellular and biological functions, many of which contribute to tumorigenesis. Here, we first present an overview of the regulation and more ‘traditional’ functions of Rho GTPases. We then discuss the consequences of deregulated Rho GTPase signaling during cancer initiation and development, and some recent developments connecting Rho GTPases to metabolic reprogramming and to the generation of cancer cell microvesicles.
| Item Type: | Book Section |
|---|---|
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > GTPase bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Rho organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell signaling organs, tissues, organelles, cell types and functions > organs types and functions > metabolism |
| CSHL Authors: | |
| Communities: | CSHL labs > Lukey lab |
| Depositing User: | Adrian Gomez |
| Date: | 20 August 2015 |
| Date Deposited: | 28 Jan 2020 17:03 |
| Last Modified: | 28 Jan 2020 17:03 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/38943 |
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