Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential

Lukey, M. J., Katt, W. P., Cerione, R. A. (May 2018) Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential. Cancer Cell, 33 (5). pp. 795-797. ISSN 1878-3686

DOI: 10.1016/j.ccell.2018.04.009


Identifying contexts in which cancer cells become addicted to specific nutrients is critical for developing targeted metabolic therapies. In this issue of Cancer Cell, Momcilovic et al. report that suppressed glycolysis following mTOR inhibition is countered by adaptive glutamine catabolism in lung squamous cell carcinoma, sensitizing tumors to glutaminase inhibition. Preview on: The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma. [Cancer Cell. 2018]

Item Type: Paper
Subjects: diseases & disorders > cancer > drugs and therapies
diseases & disorders > cancer > cancer types > lung cancer
organs, tissues, organelles, cell types and functions > organs types and functions > metabolism
CSHL Authors:
Communities: CSHL labs > Lukey lab
Depositing User: Adrian Gomez
Date: 14 May 2018
Date Deposited: 28 Jan 2020 16:08
Last Modified: 15 Nov 2023 18:56
PMCID: PMC9062989
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