Cluntun, A. A., Lukey, M. J., Cerione, R. A., Locasale, J. W. (March 2017) Glutamine Metabolism in Cancer: Understanding the Heterogeneity. Trends Cancer, 3 (3). pp. 169-180. ISSN 2405-8033
Abstract
Reliance on glutamine has long been considered a hallmark of cancer cell metabolism. However, some recent studies have challenged this notion in vivo, prompting a need for further clarifications on the role of glutamine metabolism in cancer. We find that there is ample evidence of an essential role for glutamine in tumors and that a variety of factors, including tissue type, the underlying cancer genetics, the tumor microenvironment and other variables such as diet and host physiology collectively influence the role of glutamine in cancer. Thus the requirements for glutamine in cancer are overall highly heterogeneous. In this review, we discuss the implications both for basic science and for targeting glutamine metabolism in cancer therapy.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics organs, tissues, organelles, cell types and functions > organs types and functions > metabolism diseases & disorders > cancer > drugs and therapies > tumor microenvironment |
| CSHL Authors: | |
| Communities: | CSHL labs > Lukey lab |
| Depositing User: | Adrian Gomez |
| Date: | March 2017 |
| Date Deposited: | 27 Jan 2020 16:26 |
| Last Modified: | 27 Jan 2020 16:26 |
| PMCID: | PMC5383348 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/38929 |
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