Bioactivity Evaluation of a Novel Formulated Curcumin

Liao, S. C., Hsu, W. H., Huang, Z. Y., Chuang, K. L., Lin, K. T., Tseng, C. L., Tsai, T. H., Dao, A. H., Su, C. L., Huang, C. F. (December 2019) Bioactivity Evaluation of a Novel Formulated Curcumin. Nutrients, 11 (12). ISSN 2072-6643 (Public Dataset)

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Abstract

Curcumin has been used as a traditional medicine and/or functional food in several cultures because of its health benefits including anticancer properties. However, poor oral bioavailability of curcumin has limited its oral usage as a food supplement and medical food. Here we formulated curcumin pellets using a solid dispersion technique. The pellets had the advantages of reduced particle size, improved water solubility, and particle porosity. This pellet form led to an improvement in curcumin's oral bioavailability. Additionally, we used the C-Map and Library of Integrated Network-Based Cellular Signatures (LINCS) Unified Environment (CLUE) gene expression database to determine the potential biological functions of formulated curcumin. The results indicated that, similar to conventional curcumin, the formulated curcumin acted as an NF-kappaB pathway inhibitor. Moreover, ConsensusPathDB database analysis was used to predict possible targets and it revealed that both forms of curcumin exhibit similar biological functions, including apoptosis. Biochemical characterization revealed that both the forms indeed induced apoptosis of hepatocellular carcinoma (HCC) cell lines. We concluded that the formulated curcumin increases the oral bioavailability in animals, and, as expected, retains characteristics similar to conventional curcumin at the cellular level. Our screening platform using big data not only confirms that both the forms of curcumin have similar mechanisms but also predicts the novel mechanism of the formulated curcumin.

Item Type:	Paper
Additional Information:	Nutrients
Uncontrolled Keywords:	aurora kinase A curcumin formulated curcumin hepatocellular carcinoma pharmacokinetics
Subjects:	diseases & disorders diseases & disorders > neoplasms therapies organism description > animal organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis therapies > cancer drugs - see diseases-cancer-drugs and therapies organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell proliferation organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organism description > animal > mammal organs, tissues, organelles, cell types and functions organism description > animal > mammal > rodent > rat organism description > animal > mammal > rodent > rat organism description > animal > mammal > rodent
CSHL Authors:	Lin, Kuan-Ting
Depositing User:	Adrian Gomez
Date:	6 December 2019
Date Deposited:	19 Dec 2019 16:01
Last Modified:	02 Feb 2024 16:55
PMCID:	PMC6950821
Related URLs:	Publisher
Dataset ID:	Supplement: https://www.mdpi.com/2072-6643/11/12/2982/s1.
URI:	https://repository.cshl.edu/id/eprint/38777

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