New perspectives on dimensionality and variability from large-scale cortical dynamics

Engel, T. A., Steinmetz, N. A. (October 2019) New perspectives on dimensionality and variability from large-scale cortical dynamics. Curr Opin Neurobiol, 58. pp. 181-190. ISSN 0959-4388

URL: https://www.ncbi.nlm.nih.gov/pubmed/31585331

DOI: 10.1016/j.conb.2019.09.003

Abstract

The neocortex is a multi-scale network, with intricate local circuitry interwoven into a global mesh of long-range connections. Neural activity propagates within this network on a wide range of temporal and spatial scales. At the micro scale, neurophysiological recordings reveal coordinated dynamics in local neural populations, which support behaviorally relevant computations. At the macro scale, neuroimaging modalities measure global activity fluctuations organized into spatiotemporal patterns across the entire brain. Here we review recent advances linking the local and global scales of cortical dynamics and their relationship to behavior. We argue that diverse experimental observations on the dimensionality and variability of neural activity can be reconciled by considering how activity propagates in space and time on multiple spatial scales.

Item Type:	Paper
Additional Information:	Current opinion in neurobiology
Subjects:	organism description > animal behavior organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > neocortex organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Engel, Tatiana
Communities:	CSHL labs > Engel lab
Depositing User:	Matthew Dunn
Date:	1 October 2019
Date Deposited:	07 Oct 2019 19:55
Last Modified:	02 Feb 2024 14:56
PMCID:	PMC6859189
URI:	https://repository.cshl.edu/id/eprint/38491

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