Pancreatic cancer foiled by a switch of tumour subtype

Froeling, F., Tuveson, D. (May 2018) Pancreatic cancer foiled by a switch of tumour subtype. Nature, 557 (7706). pp. 500-501. ISSN 0028-0836

URL: https://www.ncbi.nlm.nih.gov/pubmed/29777189

DOI: 10.1038/d41586-018-05129-6

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly cancers in Western society1 because it tends to be diagnosed late and responds poorly to therapy. PDAC tumours fall into two main groups2–4: a ‘classical’ subtype, and a more aggressive ‘squamous’ subtype in which pancreatic cells fail to undergo proper differentiation. The squamous subtype often involves mutations in members of the COMPASS-like complex — a group of methyltransferase and demethylase enzymes that, respectively, add or remove methyl groups from lysine amino-acid residues on histone proteins, around which DNA is packaged. Such histone modification can lead to changes in the expression of histone-associated genes involved in pancreatic-cell differentiation. Writing in Cancer Cell, Andricovich et al.5 demonstrate the role of mutations in one member of this complex, KDM6A, in driving the squamous PDAC subtype.

Item Type:	Paper
Uncontrolled Keywords:	Cancer Epigenetics
Subjects:	bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification diseases & disorders bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics diseases & disorders > neoplasms organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics organs, tissues, organelles, cell types and functions diseases & disorders > cancer > cancer types > pancreatic cancer
CSHL Authors:	Fearon, Douglas Tuveson, David A.
Communities:	CSHL labs > Fearon lab CSHL labs > Tuveson lab
Depositing User:	Matt Covey
Date:	May 2018
Date Deposited:	14 Jun 2018 20:26
Last Modified:	20 Feb 2024 19:01
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/36725

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