The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors

Je, B. I., Xu, F., Wu, Q., Liu, L., Meeley, R., Gallagher, J. P., Corcilius, L., Payne, R. J., Bartlett, M. E., Jackson, D. (March 2018) The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors. Elife, 7. ISSN 2050-084x

Abstract

Meristems contain groups of indeterminate stem cells, which are maintained by a feedback loop between CLAVATA (CLV) and WUSCHEL (WUS) signaling. CLV signaling involves the secretion of the CLV3 peptide and its perception by a number of Leucine-Rich-Repeat (LRR) receptors, including the receptor-like kinase CLV1 and the receptor-like protein CLV2 coupled with the CORYNE (CRN) pseudokinase. CLV2, and its maize ortholog FASCIATED EAR2 (FEA2) appear to function in signaling by CLV3 and several related CLV3/EMBRYO-SURROUNDING REGION (CLE) peptide ligands. Nevertheless, how signaling specificity is achieved remains unknown. Here we show that FEA2 transmits signaling from two distinct CLE peptides, the maize CLV3 ortholog ZmCLE7 and ZmFON2-LIKE CLE PROTEIN1 (ZmFCP1) through two different candidate downstream effectors, the alpha subunit of the maize heterotrimeric G protein COMPACT PLANT2 (CT2), and ZmCRN. Our data provide a novel framework to understand how diverse signaling peptides can activate different downstream pathways through common receptor proteins.

Item Type:	Paper
Uncontrolled Keywords:	CLAVATA signaling Plant Development Shoot Apical Meristem maize plant biology
Subjects:	organism description > plant > Arabidopsis bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics organism description > plant > maize organs, tissues, organelles, cell types and functions > tissues types and functions > apical meristem bioinformatics > genomics and proteomics > small molecules > cofactors bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function bioinformatics > genomics and proteomics > small molecules > cofactors > ligands organs, tissues, organelles, cell types and functions > tissues types and functions > meristem organs, tissues, organelles, cell types and functions organism description > plant organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction bioinformatics > genomics and proteomics > small molecules organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Je, Byoung Il Xu, Fang Wu, Qingyu Liu, Lei Jackson, David P.
Communities:	CSHL labs > Jackson lab
Depositing User:	Matt Covey
Date:	15 March 2018
Date Deposited:	16 Mar 2018 20:18
Last Modified:	20 Feb 2024 20:58
PMCID:	PMC5854466
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/36285

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