Draetta, G., Piwnica-Worms, H., Morrison, D., Druker, B., Roberts, T., Beach, D. (December 1988) Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature, 336 (6201). pp. 738-44. ISSN 0028-0836
DOI: 10.1038/336738a0
Abstract
cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site of cdc2 tyrosine phosphorylation in vivo is selectively phosphorylated by pp60c-src in vitro.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | CDC2 Protein Kinase *Cell Cycle Hela Cells Mitosis Phosphoproteins/*metabolism Phosphotyrosine Protein-Tyrosine Kinase/*metabolism Proto-Oncogene Protein pp60(c-src) Proto-Oncogene Proteins/metabolism Research Support, U.S. Gov't, P.H.S. Tyrosine/analogs & derivatives/metabolism |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle organs, tissues, organelles, cell types and functions > organelles, types and functions > mitosis bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > Protein kinase C |
| CSHL Authors: | |
| Communities: | CSHL labs > Beach lab |
| Depositing User: | Gail Sherman |
| Date: | 22 December 1988 |
| Date Deposited: | 17 Oct 2017 17:06 |
| Last Modified: | 17 Oct 2017 17:06 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/35139 |
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