Engel, Tatiana, Wang, Xiao-Jing (2009) Category learning and decision making: a cortical circuit model. Frontiers in Systems Neuroscience. p. 55. ISSN 1662-5137
Abstract
How does the brain recognize 'meaning' of sensory stimuli? Through experience we learn to group stimuli into arbitrary categories (such as 'animal' or 'car') according to certain shared characteristics. Recent neurophysiological studies have begun to investigate the neural mechanisms of categorization. Freedman and Assad (2006) recorded single-cell activity in monkeys classifying 360 of visual motion directions into two discrete categories. On each trial, the monkey had to indicate whether categories of two successively presented stimuli (sample and test) were the same (match) or different (nonmatch). Firing rates of neurons in the lateral intraparietal (LIP) area were found to encode the category membership of the currently visible stimulus and did not differentiate between physical features of the stimuli. In contrast, neurons in the middle temporal (MT) area were more involved in visual feature processing and did not carry explicit information about category. A similar categorization study (Freedman et al. 2003) revealed three neural populations in the prefrontal cortex (PFC): the first encoded category information, the second encoded match/nonmatch status of the test stimulus regardless of its category, and the third showed match/nonmatch effects that were limited to one of the categories. The physiological data suggest that two main computational stages are involved in this task: (i) extract the category of the sample; and (ii) perform match vs. nonmatch comparison with the test. To identify general mechanisms underlying these basic computations, we propose a biophysically plausible network model of categorization and match vs. nonmatch comparison for motion directions. The model comprises two interconnected brain areas: a sensory (MT) and a cognitive-type area (LIP/PFC). Both areas are strongly recurrent circuits with dynamics governed by slow recurrent excitation and feedback inhibition. Importantly, heterogeneity of recurrent connections within the cognitive-type circuit leads to diversity of neural responses and a continuos spectrum of neural selectivities (e.g. mixed selectivity). We hypothesize that the bottom-up synapses from MT to LIP/PFC are plastic and implement the reward-dependent stochastic Hebbian learning rule to acquire new categories. The plastic synapses shape the direction-selective input from MT to produce category-tuned responses in LIP/PFC. Match vs. nonmatch decision in the model results from the winner-take-all competition between neural pools preferring matches and nonmatches. Along with the bottom-up input from MT, these neurons receive a weak modulatory input from the category selective neurons, which biases the competition and leads to enhancement/suppression of responses to the test stimulus, depending on whether it matches the sample category. Our model accounts for the single-cell data and provides insight into general mechanisms of categorization and comparison of perceptual stimuli. The model predicts that (i) categories can be learned by synaptic plasticity in the input from sensory to cognitive-type areas; (ii) the mechanism of the match vs. nonmatch comparison is the biased winner-take-all competition.
| Item Type: | Paper |
|---|---|
| Additional Information: | Meeting abstract |
| Subjects: | organism description > animal behavior > decision making Publication Type > Meeting Abstract organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits |
| CSHL Authors: | |
| Communities: | CSHL labs > Engel lab |
| Depositing User: | Matt Covey |
| Date: | 2009 |
| Date Deposited: | 14 Aug 2017 19:12 |
| Last Modified: | 13 Mar 2018 18:38 |
| URI: | https://repository.cshl.edu/id/eprint/35093 |
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