Engel, T. A., Steinmetz, N. A., Gieselmann, M. A., Thiele, A., Moore, T., Boahen, K. (December 2016) Selective modulation of cortical state during spatial attention. Science, 354 (6316). pp. 1140-1144. ISSN 1095-9203 (Electronic)0036-8075 (Linking)
Abstract
Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchronously across cortical layers. These On-Off dynamics, reflecting global changes in cortical state, were also modulated at a local scale during selective attention. Moreover, the momentary phase of local ensemble activity predicted behavioral performance. Our results show that cortical state is controlled locally within a cortical map according to cognitive demands and reveal the impact of these local changes in cortical state on goal-directed behavior.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Attention/*physiology Brain Mapping *Goals Macaca mulatta Male Nerve Net/physiology Visual Cortex/*physiology |
| Subjects: | organism description > animal behavior > attention organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex |
| CSHL Authors: | |
| Communities: | CSHL labs > Engel lab |
| Depositing User: | Matt Covey |
| Date: | 2 December 2016 |
| Date Deposited: | 14 Aug 2017 20:49 |
| Last Modified: | 14 Aug 2017 20:49 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/35086 |
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