Ren, J., Castel, S. E., Martienssen, R. A.
(July 2015)
Dicer in action at replication-transcription collisions.
Mol Cell Oncol, 2 (3).
e991224.
ISSN 2372-3556 (Electronic)2372-3556 (Linking)
Abstract
Maintaining genome stability at sites of transcription and replication collision is a major challenge to cells. Recently, we have shown that in Schizosaccharomyces pombe Dicer promotes transcription termination at these sites, facilitating DNA replication and preventing replication fork restart that would otherwise occur via homologous recombination at the expense of genome stability. This novel role of Dicer could further explain its previously described role as a tumor suppressor.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Dicer
genome stability
replication stress
transcription termination
tumor suppressor |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dicer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > dicer
organism description > yeast |
| CSHL Authors: |
|
| Communities: |
CSHL Cancer Center Program > Gene Regulation and Inheritance Program
CSHL labs > Martienssen lab
School of Biological Sciences > Publications |
| Depositing User: |
Matt Covey
|
| Date: |
July 2015 |
| Date Deposited: |
23 Jun 2016 16:12 |
| Last Modified: |
16 Jul 2021 13:08 |
| PMCID: |
PMC4905307 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/32872 |
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