Moran, E.
(July 1993)
Interaction of adenoviral proteins with pRB and p53.
Faseb J, 7 (10).
pp. 880-5.
ISSN 0892-6638 (Print)
Abstract
The transforming gene products of the small DNA tumor viruses subvert host cell growth control mechanisms by binding to specific cell regulatory proteins. These include the retinoblastoma gene product (pRB) and p53. One indication of the pivotal roles played by these regulatory products is the observation that they are each targeted consistently by viruses of several groups, by adenoviruses, the human papillomaviruses, and the papovaviruses. In adenovirus, pRB and p53 are targeted by the E1A and E1B genes, respectively. The genetic probes made possible by manipulation of the virus genes in vitro have helped to illuminate the pathways in which pRB and p53 function. E1A studies have contributed to our current understanding that the retinoblastoma product is one of a family of related proteins, which with associated cyclins and kinases can modulate the activity of the cellular E2F transcription factor. E1B studies have helped explore models of p53 function, including the suggestion that p53, probably through aspects of its transcription regulating activity, can initiate a pathway in which programmed cell death can be invoked to stop unrestricted cell proliferation.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Adenovirus E1A Proteins/ metabolism
Adenovirus E1B Proteins/ metabolism
Amino Acid Sequence
Animals
Apoptosis/genetics
Binding Sites
Carrier Proteins
Cell Cycle/genetics
Cell Cycle Proteins
DNA-Binding Proteins
E2F Transcription Factors
Humans
Molecular Sequence Data
Research Support, U.S. Gov't, P.H.S.
Retinoblastoma Protein/ metabolism
Transcription Factor DP1
Transcription Factors/metabolism
Tumor Suppressor Protein p53/ metabolism |
| Subjects: |
organism description > virus > adenovirus
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: |
|
| Communities: |
CSHL labs |
| Depositing User: |
Matt Covey
|
| Date: |
July 1993 |
| Date Deposited: |
19 Apr 2016 21:03 |
| Last Modified: |
19 Apr 2016 21:03 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/32508 |
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