Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation

Caligiuri, M., Beach, D. (February 1993) Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation. Cell, 72 (4). pp. 607-19. ISSN 0092-8674 (Print)

Abstract

A fission yeast cell cycle START gene has been identified, sct1. Loss of sct1 function results in cell cycle arrest at START and simultaneously in derepression of the mating pathway. sct1 therefore functions both as an essential activator of the mitotic cell cycle and as a repressor of differentiation. p72sct1 shares 36% sequence similarity with p85cdc10. p72sct1 is shown to act in partnership with p85cdc10 in a cell cycle regulatory transcription complex. A single dominant mutation within the putative DNA-binding domain of p72sct1 renders the cell independent of cdc10 function for the execution of START.

Item Type:	Paper
Uncontrolled Keywords:	Amino Acid Sequence Cell Cycle Cell Cycle Proteins Cell Differentiation Comparative Study Consensus Sequence DNA-Binding Proteins/ genetics/physiology Fungal Proteins/ genetics/metabolism Gene Expression Regulation, Fungal Genes, Fungal Molecular Sequence Data Mutagenesis, Insertional Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Schizosaccharomyces/cytology/ genetics Sequence Alignment Structure-Activity Relationship Transcription Factors/ genetics/ physiology Transcription, Genetic
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell differentiation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > DNA binding protein bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:	Beach, David H. Caligiuri, Maureen
Communities:	CSHL labs > Beach lab
Depositing User:	Matt Covey
Date:	26 February 1993
Date Deposited:	22 Apr 2016 16:00
Last Modified:	22 Apr 2016 16:00
URI:	https://repository.cshl.edu/id/eprint/32491

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