MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment

Zhang, L., Sankaran, V. G., Lodish, H. F. (November 2012) MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment. Leukemia, 26 (11). pp. 2310-6. ISSN 1476-5551 (Electronic)0887-6924 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/22617791

DOI: 10.1038/leu.2012.137

Abstract

MicroRNAs (miRNAs) are a class of small regulatory noncoding RNAs that modulate the expression of their target genes through either mRNA degradation or inhibition of protein translation. In recent years, miRNAs have been shown to be critical regulators of hematopoiesis and have important roles in the differentiation of specific lineages. Here, we summarize our current understanding of miRNAs involved in hematopoiesis with a focus on the role of miRNAs in regulating erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment.

Item Type:	Paper
Uncontrolled Keywords:	Cell Differentiation/ physiology Cell Lineage Erythrocytes/ cytology Humans Megakaryocytes/ cytology MicroRNAs/genetics/ physiology
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell differentiation organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell differentiation > erythropoiesis bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell
CSHL Authors:	Zhang, Lingbo
Communities:	CSHL labs > Zhang L. lab
Depositing User:	Matt Covey
Date:	November 2012
Date Deposited:	13 Jul 2015 19:59
Last Modified:	13 Jul 2015 19:59
PMCID:	PMC3739046
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/31619

Actions (login required)

Administrator's edit/view item