Yin, J. C., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., Tully, T. (October 1994) Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell, 79 (1). pp. 49-58. ISSN 0092-8674 (Print)
Abstract
Consolidated memory after olfactory learning in Drosophila consists of two components, a cycloheximide-sensitive, long-term memory (LTM) and a cycloheximide-insensitive, anesthesia-resistant memory (ARM). Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected. These results suggest that LTM formation requires de novo gene expression probably mediated by CREB family genes.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Amino Acid Sequence Animals Animals, Genetically Modified Conditioning, Classical Cyclic AMP Response Element-Binding Protein/ genetics/physiology Drosophila/ genetics/physiology Gene Expression Genes, Dominant/physiology Genes, Insect/ physiology Heat Memory/ physiology Molecular Sequence Data RNA, Messenger/biosynthesis Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. |
| Subjects: | organism description > animal > insect > Drosophila organism description > animal behavior > memory |
| CSHL Authors: | |
| Communities: | CSHL labs > Tully lab |
| Depositing User: | Matt Covey |
| Date: | 7 October 1994 |
| Date Deposited: | 27 Aug 2015 15:08 |
| Last Modified: | 27 Aug 2015 15:08 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31414 |
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