Lovering, R., Hanson, I. M., Borden, K. L., Martin, S., O'Reilly, N. J., Evan, G. I., Rahman, D., Pappin, D. J., Trowsdale, J., Freemont, P. S. (March 1993) Identification and preliminary characterization of a protein motif related to the zinc finger. Proc Natl Acad Sci U S A, 90 (6). pp. 2112-6. ISSN 0027-8424 (Print)0027-8424 (Linking)
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Abstract
We have identified a protein motif, related to the zinc finger, which defines a newly discovered family of proteins. The motif was found in the sequence of the human RING1 gene, which is proximal to the major histocompatibility complex region on chromosome six. We propose naming this motif the "RING finger" and it is found in 27 proteins, all of which have putative DNA binding functions. We have synthesized a peptide corresponding to the RING1 motif and examined a number of properties, including metal and DNA binding. We provide evidence to support the suggestion that the RING finger motif is the DNA binding domain of this newly defined family of proteins.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Amino Acid Sequence Animals Base Sequence Cell Line Cobalt/metabolism DNA/genetics/metabolism DNA-Binding Proteins/chemistry/ genetics/metabolism HeLa Cells Humans Molecular Sequence Data Oncogenes Poly A/genetics/isolation & purification Polycomb Repressive Complex 1 Protein Binding Protein Structure, Secondary RNA/genetics/isolation & purification RNA, Messenger Sequence Homology, Amino Acid Spectrophotometry Tumor Cells, Cultured Zinc/metabolism Zinc Fingers/ genetics |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein characterization bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > zinc finger proteins |
| CSHL Authors: | |
| Communities: | CSHL labs > Pappin lab |
| Depositing User: | Matt Covey |
| Date: | 15 March 1993 |
| Date Deposited: | 18 Sep 2014 15:28 |
| Last Modified: | 09 Nov 2017 20:01 |
| PMCID: | PMC46035 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30759 |
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