Galaktionov, K., Lee, A. K., Eckstein, J., Draetta, G., Meckler, J., Loda, M., Beach, D. (September 1995) CDC25 phosphatases as potential human oncogenes. Science, 269 (5230). pp. 1575-7. ISSN 0036-8075 (Print)
Abstract
Cyclin-dependent kinases (CDKs) are activated by CDC25 phosphatases, which remove inhibitory phosphate from tyrosine and threonine residues. In human cells, CDC25 proteins are encoded by a multigene family, consisting of CDC25A, CDC25B, and CDC25C. In rodent cells, human CDC25A or CDC25B but not CDC25C phosphatases cooperate with either Ha-RASG12V or loss of RB1 in oncogenic focus formation. Such transformants were highly aneuploid, grew in soft agar, and formed high-grade tumors in nude mice. Overexpression of CDC25B was detected in 32 percent of human primary breast cancers tested. The CDC25 phosphatases may contribute to the development of human cancer.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Breast Neoplasms/genetics Cell Cycle Proteins/ genetics Cell Division Cell Transformation, Neoplastic Cells, Cultured Gene Expression Genes, Retinoblastoma Genes, p53 Genes, ras Humans In Situ Hybridization Mice Mice, Inbred BALB C Mice, Nude Multigene Family Neoplasm Transplantation Oncogenes Phosphoprotein Phosphatase/ genetics Prognosis Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Transfection Tumor Cells, Cultured cdc25 Phosphatase |
| Subjects: | diseases & disorders > neoplasms organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell division bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression organism description > animal > mammal > primates > hominids > human organism description > animal > mammal > rodent > mouse bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene |
| CSHL Authors: | |
| Communities: | CSHL labs > Beach lab |
| Depositing User: | Jessica Koos |
| Date: | 15 September 1995 |
| Date Deposited: | 14 Aug 2014 14:45 |
| Last Modified: | 14 Aug 2014 14:45 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30593 |
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