DeZazzo, J., Tully, T. (May 1995) Dissection of memory formation: from behavioral pharmacology to molecular genetics. Trends Neurosci, 18 (5). pp. 212-8. ISSN 0166-2236 (Print)
Abstract
Behavioral pharmacology has suggested an intricate, multiphasic pathway of memory consolidation. An integrated molecular pharmacological approach in Drosophila has lent support to this theory recently by dissecting consolidated memory into two genetically distinct components: a cycloheximide-insensitive, anesthesia-resistant memory and a cycloheximide-sensitive long-term memory. In addition, experiments using inducible dominant-negative transgenes in Drosophila or gene knockouts in mice demonstrate a role for cAMP-responsive transcription factors in formation of long-term memory. These studies support the application of reverse-genetic strategies, including the use of temporally specific agonists and antagonists, to advance the functional dissection of memory formation.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Cyclic AMP/pharmacology Cycloheximide/pharmacology Drosophila Genes Memory/ physiology Molecular Biology Neural Pathways/physiology Neuropharmacology Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Time Factors Transcription Factors |
| Subjects: | organism description > animal > insect > Drosophila organism description > animal bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function organism description > animal behavior > memory bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: | |
| Communities: | CSHL labs > Tully lab |
| Depositing User: | Jessica Koos |
| Date: | May 1995 |
| Date Deposited: | 12 Aug 2014 13:56 |
| Last Modified: | 12 Aug 2014 13:56 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30588 |
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