Aznar, S., Klein, A. B., Santini, M. A., Knudsen, G. M., Henn, F., Gass, P., Vollmayr, B. (July 2010) Aging and depression vulnerability interaction results in decreased serotonin innervation associated with reduced BDNF levels in hippocampus of rats bred for learned helplessness. Synapse, 64 (7). pp. 561-5. ISSN 0887-4476
Abstract
Epidemiological studies have revealed a strong genetic contribution to the risk for depression. Both reduced hippocampal serotonin neurotransmission and brain-derived neurotrophic factor (BDNF) levels have been associated with increased depression vulnerability and are also regulated during aging. Brains from young (5 months old) and old (13 months old) congenital Learned Helplessness rats (cLH), and congenital Non Learned Helplessness rats (cNLH) were immunohistochemically stained for the serotonin transporter and subsequently stereologically quantified for estimating hippocampal serotonin fiber density. Hippocampal BDNF protein levels were measured by ELISA. An exacerbated age-related loss of serotonin fiber density specific for the CA1 area was observed in the cLH animals, whereas reduced hippocampal BDNF levels were seen in young and old cLH when compared with age-matched cNLH controls. These observations indicate that aging should be taken into account when studying the neurobiological factors behind the vulnerability for depression and that understanding the effect of aging on genetically predisposed individuals may contribute to a better understanding of the pathophysiology behind depression, particularly in the elderly.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Aging/*metabolism Animals Brain-Derived Neurotrophic Factor/*metabolism CA1 Region, Hippocampal/metabolism CA3 Region, Hippocampal/metabolism Cell Count Depression/*metabolism Enzyme-Linked Immunosorbent Assay Helplessness, Learned Hippocampus/*metabolism Immunohistochemistry Neurons/metabolism Rats Rats, Sprague-Dawley Serotonin/*metabolism Serotonin Plasma Membrane Transport Proteins/*metabolism Species Specificity |
| Subjects: | diseases & disorders > mental disorders bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > brain derived neurotrophic factor diseases & disorders > mental disorders > mood disorders > depression organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus organism description > animal > mammal > rodent > rat organism description > animal > mammal > rodent > rat |
| CSHL Authors: | |
| Communities: | CSHL labs > Henn lab |
| Depositing User: | Matt Covey |
| Date: | July 2010 |
| Date Deposited: | 06 Jun 2014 16:24 |
| Last Modified: | 06 Jun 2014 16:24 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30274 |
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