Henn, F. A.
(August 1978)
Dopamine and schizophrenia. A therapy revisited and revised.
Lancet, 2 (8084).
pp. 293-5.
ISSN 0140-6736 (Print)0140-6736
Abstract
Evidence is presented for a modulatory role for dopamine in the C.N.S. and for an indirect rather than a direct involvement of dopaminergic systems in the production of schizophrenic symptoms. The fine structure of dopaminergic fibres indicates that a majority of presynaptic boutons are not in close juxtaposition with postsynaptic neuronal membranes. This points to a wider distribution of receptors than localisation to dense postsynaptic membrane. Preliminary studies of receptor localisation support this conclusion, providing indirect evidence for autoreceptors and evidence for localisation, in the glia, of a substantial number of receptors.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Adenylate Cyclase/antagonists & inhibitors/metabolism
Animals
Astrocytes/analysis/enzymology
Cattle
Caudate Nucleus/cytology
Cyclic AMP/biosynthesis
Dopamine/*physiology
Haloperidol/pharmacology
Humans
Phenothiazines/pharmacology
Rabbits
Rats
Receptors, Dopamine/drug effects/isolation & purification/*physiology
Schizophrenia/*etiology |
| Subjects: |
diseases & disorders > mental disorders > schizophrenia
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Henn lab |
| Depositing User: |
Matt Covey
|
| Date: |
5 August 1978 |
| Date Deposited: |
09 Jul 2014 15:24 |
| Last Modified: |
09 Jul 2014 15:24 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/30214 |
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