Deficiency in induction but not expression of LTP in hippocampal slices from young rats

Liao, D., Malinow, R. (September 1996) Deficiency in induction but not expression of LTP in hippocampal slices from young rats. Learn Mem, 3 (2-3). pp. 138-49. ISSN 1072-0502 (Print)

DOI: 10.1101/lm.3.2-3.138


In this study we examine developmental changes between postnatal day (PND) 4 and 14 in synaptic transmission and plasticity in the CA1 region of hippocampal slices. We confirm previous results that tetanus-induced long-term potentiation (LTP) in field recordings is diminished in slices from younger animals. LTP in whole-cell current-clamp recordings is also diminished in younger animals. However, robust LTP can be induced in young animals if sufficient postsynaptic depolarization is provided during LTP induction. Furthermore, we find differences in synaptic transmission between PND 4 and 14, suggesting that the depolarization during tetanic stimulation in young tissue is ineffective to produce LTP. These results indicate that the smaller potentiation in field recordings in slices from younger animals is attributable to insufficient postsynaptic depolarization during LTP induction rather than a defect in expression mechanisms.

Item Type: Paper
Uncontrolled Keywords: Aging/ physiology Animals Animals, Newborn/growth & development/ physiology Electric Stimulation Electrophysiology Excitatory Postsynaptic Potentials/physiology Hippocampus/ physiology In Vitro Long-Term Potentiation/ physiology Rats Synapses/physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation
organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus
organism description > animal behavior > memory
organism description > animal > mammal > rodent > rat
organism description > animal > mammal > rodent > rat
CSHL Authors:
Communities: CSHL labs > Malinow lab
Depositing User: Matt Covey
Date: September 1996
Date Deposited: 22 May 2014 14:29
Last Modified: 22 May 2014 14:29
Related URLs:

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving