Liao, D., Malinow, R. (September 1996) Deficiency in induction but not expression of LTP in hippocampal slices from young rats. Learn Mem, 3 (2-3). pp. 138-49. ISSN 1072-0502 (Print)
Abstract
In this study we examine developmental changes between postnatal day (PND) 4 and 14 in synaptic transmission and plasticity in the CA1 region of hippocampal slices. We confirm previous results that tetanus-induced long-term potentiation (LTP) in field recordings is diminished in slices from younger animals. LTP in whole-cell current-clamp recordings is also diminished in younger animals. However, robust LTP can be induced in young animals if sufficient postsynaptic depolarization is provided during LTP induction. Furthermore, we find differences in synaptic transmission between PND 4 and 14, suggesting that the depolarization during tetanic stimulation in young tissue is ineffective to produce LTP. These results indicate that the smaller potentiation in field recordings in slices from younger animals is attributable to insufficient postsynaptic depolarization during LTP induction rather than a defect in expression mechanisms.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Aging/ physiology Animals Animals, Newborn/growth & development/ physiology Electric Stimulation Electrophysiology Excitatory Postsynaptic Potentials/physiology Hippocampus/ physiology In Vitro Long-Term Potentiation/ physiology Rats Synapses/physiology |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > Long term potentiation organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus organism description > animal behavior > memory organism description > animal > mammal > rodent > rat organism description > animal > mammal > rodent > rat |
| CSHL Authors: | |
| Communities: | CSHL labs > Malinow lab |
| Depositing User: | Matt Covey |
| Date: | September 1996 |
| Date Deposited: | 22 May 2014 14:29 |
| Last Modified: | 22 May 2014 14:29 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30179 |
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