Grand, R. S., Martienssen, R., O'Sullivan, J. M. (May 2014) Potential roles for interactions between the mitochondrial and nuclear DNA throughout the cell cycle of Schizosaccharomyces pombe. Mitochondrion, 17. pp. 141-9. ISSN 1567-7249
Abstract
Over the course of mitochondrial evolution, the majority of genes required for its function have been transferred and integrated into nuclear chromosomes. Ongoing transfer of mitochondrial DNA to the nucleus has been detected, but its functional significance has not been fully elucidated. Here by Genome Conformation Capture, we identify DNA-DNA interactions between the mitochondrial and nuclear chromosomes (mt-nDNA interactions) that vary in strength and number between the G1, G2 and M phases of the fission yeast cell cycle. Mt-nDNA interactions captured in mitotic anaphase were associated with nuclear genes required for the regulation of cell growth and energy availability. Furthermore, mt-nDNA interactions captured in the G1 phase involved high efficiency, early firing origins of DNA replication. Collectively, these results suggest functional roles for the ongoing transfer of regions of the mitochondrial genome to the nucleus.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Cell cycle Communication DNA replication Genome Conformation Capture (GCC) Mitochondria Regulation |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification organs, tissues, organelles, cell types and functions > organelles, types and functions > mitochondria organism description > yeast |
| CSHL Authors: | |
| Communities: | CSHL labs > Martienssen lab CSHL Cancer Center Program > Gene Regulation and Cell Proliferation |
| Depositing User: | Matt Covey |
| Date: | 7 May 2014 |
| Date Deposited: | 15 May 2014 19:16 |
| Last Modified: | 06 Oct 2015 21:14 |
| PMCID: | PMC4209164 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30140 |
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