Zhang, M. Q. (January 1997) Identification of protein coding regions in the human genome by quadratic discriminant analysis. Proceedings of the National Academy of Sciences, 94 (2). pp. 565-8. ISSN 0027-8424 (Print)
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Abstract
A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the quadratic discriminant function for multivariate statistical pattern recognition. Substantial improvements have been made (with only 9 discriminant variables) when compared with existing methods: HEXON [Solovyev, V. V., Salamov, A. A. & Lawrence, C. B. (1994) Nucleic Acids Res. 22, 5156-5163] (based on linear discriminant analysis) and GRAIL2 [Uberbacher, E. C. & Mural, R. J. (1991) Proc. Natl. Acad. Sci. USA 88, 11261-11265] (based on neural networks). A computer program called MZEF is freely available to the genome community and allows users to adjust prior probability and to output alternative overlapping exons.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Base Sequence Exons Genes Human Genome Project Humans Molecular Sequence Data Multivariate Analysis Proteins/genetics Research Support, U.S. Gov't, P.H.S. Sequence Analysis, DNA/ methods Software |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > exons > protein coding exon |
| CSHL Authors: | |
| Communities: | CSHL labs > Zhang lab |
| Depositing User: | Kathleen Darby |
| Date: | 21 January 1997 |
| Date Deposited: | 08 May 2014 18:31 |
| Last Modified: | 11 Sep 2019 17:00 |
| PMCID: | PMC19553 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29970 |
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