The INK4 family of CDK inhibitors

Carnero, A., Hannon, G. J. (1998) The INK4 family of CDK inhibitors. Current Topics in Microbiology and Immunology, 227. pp. 43-55. ISSN 0070-217X (Print)

DOI: 10.1007/978-3-642-71941-7_3


Decisions concerning the fate of a cell are intimately linked to the proliferative state of that cell. Proliferation of certain cell populations is required to maintain or repair tissues in an aging organism. However, this proliferation must be tightly regulated. Failure to control proliferation may interfere with differentiation, causing a cell to fail to achieve its fully determined state. Potentially more severe consequences could also ensue from uncontrolled cell division. When this is accompanied by a failure of programmed cell death, a cancerous tumor can result.

Item Type: Paper
Uncontrolled Keywords: Animals Carrier Proteins/genetics/ metabolism Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor p15 Cyclin-Dependent Kinase Inhibitor p16/genetics/ metabolism Cyclin-Dependent Kinase Inhibitor p18 Cyclin-Dependent Kinase Inhibitor p19 Cyclin-Dependent Kinases/ antagonists & inhibitors Enzyme Inhibitors/ metabolism Humans Tumor Suppressor Proteins
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > tumor suppressor
CSHL Authors:
Communities: CSHL labs > Hannon lab
CSHL labs > Beach lab
Depositing User: Kathleen Darby
Date: 1998
Date Deposited: 05 May 2014 14:06
Last Modified: 07 May 2014 13:24
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