Grange, Pascal, Hawrylycz, Michael, Mitra, Partha P. (2013) Computational neuroanatomy and co-expression of genes in the adult mouse brain, analysis tools for the Allen Brain Atlas. Quantitative Biology, 1 (1). pp. 91-100. ISSN 2095-4689
Abstract
We review quantitative methods and software developed to analyze genome-scale, brain-wide spatially-mapped gene-expression data. We expose new methods based on the underlying high-dimensional geometry of voxel space and gene space, and on simulations of the distribution of co-expression networks of a given size. We apply them to the Allen Atlas of the adult mouse brain, and to the coexpression network of a set of genes related to nicotine addiction retrieved from the NicSNP database. The computational methods are implemented in BrainGeneExpressionAnalysis (BGEA), a Matlab toolbox available for download.
| Item Type: | Paper |
|---|---|
| Subjects: | Investigative techniques and equipment > brain atlas bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function organism description > animal > mammal > rodent > mouse neurobiology Investigative techniques and equipment > Whole Brain Circuit Mapping |
| CSHL Authors: | |
| Communities: | CSHL labs > Mitra lab |
| Depositing User: | Matt Covey |
| Date: | 2013 |
| Date Deposited: | 21 Apr 2014 18:33 |
| Last Modified: | 21 Apr 2014 18:33 |
| URI: | https://repository.cshl.edu/id/eprint/29775 |
Actions (login required)
 |
Administrator's edit/view item |