McCarthy, S. E., McCombie, W. R., Corvin, A. (March 2014) Unlocking the Treasure Trove: From Genes to Schizophrenia Biology. Schizophrenia Bulletin, 40 (3). pp. 492-496. ISSN 0586-7614
Abstract
Significant progress is being made in defining the genetic etiology of schizophrenia. As the list of implicated genes grows, parallel developments in gene editing technology provide new methods to investigate gene function in model systems. The confluence of these two research fields-gene discovery and functional biology-may offer novel insights into schizophrenia etiology. We review recent advances in these fields, consider the likely obstacles to progress, and consider strategies as to how these can be overcome.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Crispr genomics model schizophrenia sequencing systems |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification diseases & disorders > mental disorders diseases & disorders > mental disorders > schizophrenia bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes Investigative techniques and equipment > assays > next generation sequencing Investigative techniques and equipment > assays > whole genome sequencing |
| CSHL Authors: | |
| Communities: | CSHL labs > McCombie lab |
| Depositing User: | Matt Covey |
| Date: | 27 March 2014 |
| Date Deposited: | 11 Apr 2014 19:44 |
| Last Modified: | 18 Dec 2014 17:18 |
| PMCID: | PMC3984532 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29738 |
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