Hoeppner, D. J., Hengartner, M. O., Schnabel, R. (July 2001) Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature, 412 (6843). pp. 202-206. ISSN 0028-0836
Abstract
Genetic studies have identified over a dozen genes that function in programmed cell death (apoptosis) in the nematode Caenorhabditis elegans(1-3). Although the ultimate effects on cell survival or engulfment of mutations in each cell death gene have been extensively described, much less is known about how these mutations affect the kinetics of death and engulfment, or the interactions between these two processes. We have used four-dimensional-Nomarski time-lapse video microscopy to follow in detail how cell death genes regulate the extent and kinetics of apoptotic cell death and removal in the early C. elegans embryo. Here we show that blocking engulfment enhances cell survival when cells are subjected to weak pro-apoptotic signals. Thus, genes that mediate corpse removal can also function to actively kill cells.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | C-ELEGANS APOPTOSIS PROTEIN GENETICS NEMATODE CORPSES |
| Subjects: | organism description > animal > C elegans organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function |
| CSHL Authors: | |
| Communities: | CSHL labs > Hengartner lab |
| Depositing User: | Matt Covey |
| Date: | July 2001 |
| Date Deposited: | 21 Jan 2014 16:28 |
| Last Modified: | 21 Jan 2014 16:28 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/29251 |
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