Sun, H., Tonks, N. K., Barsagi, D.
(October 1994)
Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1.
Science, 266 (5183).
pp. 285-288.
ISSN 0036-8075
Abstract
Mitogen-activated protein kinases (MAP kinases) are common components of signaling pathways induced by diverse growth stimuli. Although the guanidine nucleotide-binding Ras proteins are known to be upstream activators of MAP kinases, the extent to which MAP kinases directly contribute to the mitogenic effect of Ras is as yet undefined. In this study, inhibition of MAP kinases by the MAP kinase phosphatase MKP-1 blocked the induction of DNA synthesis in quiescent rat embryonic fibroblast REF-52 cells by an activated mutant of Ras, V(12)Ras. These results suggest an essential role for activation of MAP kinases in the transition from the quiescent to the DNA replication phase of the eukaryotic cell cycle.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
ACTIVATED PROTEIN-KINASES
IMMEDIATE-EARLY GENE
MAP KINASE
SIGNAL-TRANSDUCTION
PHOSPHORYLATION
PROLIFERATION
PATHWAY
DOMAIN |
| Subjects: |
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > immediate early genes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein phosphatase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > G protein > Ras |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Tonks lab |
| Depositing User: |
Matt Covey
|
| Date: |
October 1994 |
| Date Deposited: |
18 Dec 2013 15:19 |
| Last Modified: |
18 Dec 2013 15:19 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/29064 |
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