Johnstone, R. W., Ruefli, A. A., Lowe, S. W. (January 2002) Apoptosis: A link between cancer genetics and chemotherapy. Cell, 108 (2). pp. 153-164. ISSN 0092-8674
Abstract
Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis diseases & disorders > cancer > drugs and therapies > chemotherapy |
| CSHL Authors: | |
| Communities: | CSHL labs > Lowe lab |
| Depositing User: | Matt Covey |
| Date: | January 2002 |
| Date Deposited: | 08 Jan 2014 17:03 |
| Last Modified: | 08 Jan 2014 17:03 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28727 |
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