Azumi, Y., Liu, D. H., Zhao, D. Z., Li, W. X., Wang, G. F., Hu, Y., Ma, H. (June 2002) Homolog interaction during meiotic prophase I in Arabidopsis requires the SOLO DANCERS gene encoding a novel cyclin-like protein. Embo Journal, 21 (12). pp. 3081-3095. ISSN 0261-4189
Abstract
Interactions between homologs in meiotic prophase I, such as recombination and synapsis, are critical for proper homolog segregation and involve the coordination of several parallel events. However, few regulatory genes have been identified; in particular, it is not clear what roles the proteins similar to the mitotic cell cycle regulators might play during meiotic prophase I. We describe here the isolation and characterization of a new Arabidopsis mutant called solo dancers that exhibits a severe defect in homolog synapsis, recombination and bivalent formation in meiotic prophase I, subsequently resulting in seemingly random chromosome distribution and formation of abnormal meiotic products. We further demonstrate that the mutation affects a meiosis-specific gene encoding a novel protein of 578 amino acid residues with up to 31% amino acid sequence identity to known cyclins in the C-terminal portion. These results argue strongly that homolog interactions during meiotic prophase I require a novel meiosis-specific cyclin in Arabidopsis.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > plant > Arabidopsis bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function organs, tissues, organelles, cell types and functions > organelles, types and functions > meiosis organism description > plant |
| CSHL Authors: | |
| Communities: | School of Biological Sciences > Publications |
| Depositing User: | Matt Covey |
| Date: | June 2002 |
| Date Deposited: | 09 Jan 2014 15:17 |
| Last Modified: | 09 Sep 2021 18:43 |
| PMCID: | PMC126045 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28665 |
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