Koulakov, A. A., Raghavachari, S., Kepecs, A., Lisman, J. E.
(2002)
Model for a robust neural integrator.
Nature Neuroscience, 5 (8).
pp. 775-782.
ISSN 10976256 (ISSN)
Abstract
Integrator circuits in the brain show persistent firing that reflects the sum of previous excitatory and inhibitory inputs from external sources. Integrator circuits have been implicated in parametric working memory, decision making and motor control. Previous work has shown that stable integrator function can be achieved by an excitatory recurrent neural circuit, provided synaptic strengths are tuned with extreme precision (better than 1% accuracy). Here we show that integrator circuits can function without fine tuning if the neuronal units have bistable properties. Two specific mechanisms of bistability are analyzed, one based on local recurrent excitation, and the other on the voltage-dependence of the NMDA (N-methyl-D-aspartate) channel. Neither circuit requires fine tuning to perform robust integration, and the latter actually exploits the variability of neuronal conductances.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
n methyl dextro aspartic acid
accuracy
article
cell membrane potential
channel gating
excitation
memory
motor control
nerve cell network
nerve conduction
priority journal
synapse
Computer Simulation
Models, Neurological
Neural Networks (Computer)
Neurons
Receptors, N-Methyl-D-Aspartate
Reproducibility of Results |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > NMDA receptor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > tissues types and functions > neural networks
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Kepecs lab
CSHL labs > Koulakov lab |
| Depositing User: |
Matt Covey
|
| Date: |
2002 |
| Date Deposited: |
10 Apr 2013 20:19 |
| Last Modified: |
22 Jul 2015 20:23 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/28116 |
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