Sartorius, A., Vollmayr, B., Neumann-Haefelin, C., Ende, G., Hoehn, M., Henn, F. A. (December 2003) Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment. Neuroreport, 14 (17). pp. 2199-201. ISSN 0959-4965 (Print)0959-4965 (Linking)
Abstract
Metabolic changes in the hippocampus formation can be investigated with in vivo magnetic resonance spectroscopy (MRS). Learned helplessness (LH) is a well validated animal model of depression which we established in Sprague-Dawley rats defining some as "learned helpless" (LH) or not "learned helpless" (NLH). Helpless and non-helpless rats received a course of daily administered electroconvulsive shocks (ECS) for 6 days. MRS measurements were performed on a 4.7 T animal scanner with an average voxel size within the rat hippocampus of 10 microl. In LH rats hippocampal creatine/NAA rose significantly (14%) whereas creatine/NAA of NLH rats showed no increase at all. A possible connection between hippocampal creatine levels and major depressive disorders as a reflection of changes in energy metabolism is discussed.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Creatine/ metabolism Electroconvulsive Therapy/ methods Helplessness, Learned Hippocampus/ metabolism Magnetic Resonance Spectroscopy/methods Male Rats Rats, Sprague-Dawley |
| Subjects: | diseases & disorders diseases & disorders > mental disorders diseases & disorders > mental disorders > mood disorders therapies organism description > animal behavior diseases & disorders > mental disorders > mood disorders > depression |
| CSHL Authors: | |
| Communities: | CSHL labs > Henn lab |
| Depositing User: | Matt Covey |
| Date: | 2 December 2003 |
| Date Deposited: | 01 Apr 2013 18:42 |
| Last Modified: | 01 Apr 2013 18:42 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28010 |
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