Tonks, N. K.
(July 2003)
PTP1B: From the sidelines to the front lines!
Febs Letters, 546 (1).
pp. 140-148.
ISSN 0014-5793
Abstract
Although initially viewed as housekeeping enzymes, research over the last 15 years has revealed that the protein tyrosine phosphatases (PTPs) are critical regulators of tyrosine phosphorylation-dependent signaling events and may represent novel targets for therapeutic intervention in a variety of human diseases. In this review I will describe some of the key advances in the characterization of the structure, regulation and function of the prototypic PTP, PTP1B, and illustrate how our understanding of the properties of this enzyme has revealed principles that apply to the PTP family as a whole. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
PTP1B
tyrosine phosphatase
signal transduction
drug development
PROTEIN-TYROSINE-PHOSPHATASE
STRUCTURE-BASED DESIGN
1B IN-VIVO
GROWTH-FACTOR
INSULIN SENSITIVITY
STRUCTURAL BASIS
HUMAN-PLACENTA
REVERSIBLE INACTIVATION
ENDOPLASMIC-RETICULUM
SIGNAL-TRANSDUCTION |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction
organs, tissues, organelles, cell types and functions > tissues types and functions
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Tonks lab |
| Depositing User: |
Matt Covey
|
| Date: |
July 2003 |
| Date Deposited: |
11 Jun 2013 15:00 |
| Last Modified: |
11 Jun 2013 15:00 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/27948 |
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