Sartorius, A., Neumann-Haefelin, C., Vollmayr, B., Hoehn, M., Henn, F. A. (April 2003) Choline rise in the rat hippocampus induced by electroconvulsive shock treatment. Biological Psychiatry, 53 (7). pp. 620-3. ISSN 0006-3223
Abstract
BACKGROUND: Human hippocampal choline decreases in major depression episodes. This decrease was recently measured by 1H magnetic resonance spectroscopy (MRS), and it has been found that its level normalizes during antidepressive electroconvulsive therapy. We hypothesized a hippocampal choline increase in the rat brain under electroconvulsive shock (ECS) treatment. METHODS: Rat hippocampi (n = 28) were investigated via magnetic resonance spectroscopy and signal intensities of choline (Cho), total creatine (tCr), and N-acetyl aspartate (NAA) were measured and expressed as ratios before and after six ECS treatments. RESULTS: After ECS treatment, hippocampal choline increases significantly: Cho/tCr ratio: +13% and Cho/NAA ratio: +19% increase. CONCLUSIONS: We found a rise of relative choline concentration induced by ECS treatment in rat hippocampus measured in vivo with magnetic resonance spectroscopy. This increase corresponds to the increase of choline in human hippocampus after electroconvulsive shock treatment. Because choline measured via 1H-spectroscopy is believed to represent primarily phosphocholine and glycerophosphocholine, and therefore phospholipase A2 activity and membrane turnover, our results are in good agreement with reported ECS-induced hippocampal mossy fiber sprouting, increased synaptic plasticity, and neurogenesis.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Choline/analysis/ metabolism Depressive Disorder/metabolism/ therapy Electroconvulsive Therapy Hippocampus/ metabolism Magnetic Resonance Spectroscopy Rats Rats, Sprague-Dawley |
| Subjects: | organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus organism description > animal > mammal > rodent > rat organism description > animal > mammal > rodent > rat organs, tissues, organelles, cell types and functions > tissues types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Henn lab |
| Depositing User: | Matt Covey |
| Date: | 1 April 2003 |
| Date Deposited: | 28 Jun 2013 19:09 |
| Last Modified: | 28 Jun 2013 19:09 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27912 |
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