Mills, A. A., Zheng, B., Wang, X. J., Vogel, H., Roop, D. R., Bradley, A.
(1999)
p63 is a p53 homologue required for limb and epidermal morphogenesis.
Nature, 398 (6729).
pp. 708-713.
ISSN 00280836 (ISSN)
Abstract
The p53 tumour suppressor is a transcription factor that regulates the progression of the cell through its cycle and cell death (apoptosis) in response to environmental stimuli such as DNA damage and hypoxia. Even though p53 modulates these critical cellular processes, mice that lack p53 are developmentally normal, suggesting that p53-related proteins might compensate for the functions of p53 during embryogenesis. Two p53 homologues, p63 and p73, are known and here we describe the function of p63 in vivo. Mice lacking p63 are born alive but have striking developmental defects. Their limbs are absent or truncated, defects that are caused by a failure of the apical ectodermal ridge to differentiate. The skin of p63-deficient mice does not progress past an early developmental stage: it lacks stratification and does not express differentiation markers. Structures dependent upon epidermal- mesenchymal interactions during embryonic development, such as hair follicles, teeth and mammary glands, are absent in p63-deficient mice. Thus, in contrast to p53, p63 is essential for several aspects of ectodermal differentiation during embryogenesis.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
protein derivative
protein p53
protein p63
unclassified drug
animal experiment
animal tissue
article
embryo development
epidermis cell
gene expression
limb development
morphogenesis
mouse
nonhuman
pathological anatomy
priority journal
protein analysis
sequence homology
Animals
Body Patterning
Epidermis
Female
Forelimb
Gene Expression Regulation, Developmental
Gene Transfer Techniques
Genes, p53
Hindlimb
Limb Bud
Limb Deformities, Congenital
Male
Membrane Proteins
Mice
Mice, Inbred C57BL
Phosphoproteins
Trans-Activators |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p63 |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Mills lab |
| Depositing User: |
Matt Covey
|
| Date: |
1999 |
| Date Deposited: |
11 Mar 2013 20:27 |
| Last Modified: |
11 Mar 2013 20:27 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/27761 |
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